Vitamin D Levels in Children with Adenotonsillar Hypertrophy and Otitis Media with Effusion

Asghari A1, Bagheri Z2, Jalessi M2, Salem MM2, Amini E2, GhalehBaghi S2, Bakhti S2

Abstract

INTRODUCTION:

Vitamin D has been suggested to play a considerable role in the function of the immune system in various infectious, inflammatory, and autoimmune conditions. Otitis media with effusion (OME), defined as the presence of non-purulent fluid within the middle ear without signs or symptoms of suppurative otitis media, has a number of inflammatory predisposing factors. This study was designed to explore the association between vitamin D deficiency and OME.

MATERIALS AND METHODS:

In this cross-sectional study, 74 children aged 2-7 years with an obstructive indication for adenotonsillectomy were included. Patients were divided into two groups based on the need for ventilation tube insertion for OME. Thirty-two children were enrolled in the OME group and 42 in the control group. The mean vitamin D level was compared between the two groups.

RESULTS:

Mean vitamin D concentration in all patients was 11.96±۵٫۸۵ ng/ml (9.79±۴٫۳۶ ng/ml in the OME group and 13.61±۶٫۳۳ ng/ml in the control group; P=0.003). There was also a significant difference in levels of vitamin D in patients referred in winter (9.0±۲٫۹۴ ng/ml) compared with the summer (19.85±۴٫۲۱ ng/ml; P=0.001). Data analyzed based on the season in which the patients were referred showed no significant difference between the OME and the control group.

CONCLUSION:

Although our results showed lower serum levels of vitamin D in OME patients, the difference was not significant when seasons were taken into consideration. Therefore, the season is an important confounding factor in any research related to vitamin D due to the effect of sun-induced vitamin D.

KEYWORDS:

Adenoids; Child; Otitis Media; Seasons; Vitamin D